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1.
Подробнее
K 46
Kinch, Michael, (1966-).
A prescription for change : : the looming crisis in drug development / / Michael S. Kinch. - Chapel Hill : : The University of North Carolina Press,, 2016. - 1 online resource (xi, 339 pages). - (The Luther H. Hodges Jr. and Luther H. Hodges Sr. series on business, entrepreneurship, and public policy). - Includes bibliographical references and index. - URL: https://library.dvfu.ru/lib/document/SK_ELIB/528D36D6-0AF5-481D-8D93-B30C48AA36D7. - ISBN 1469630648 (electronic bk.). - ISBN 9781469630649 (electronic bk.)
Print version record.
Параллельные издания: Print version: : Kinch, Michael S. Prescription for change. - Chapel Hill : University of North Carolina Press, [2016]. - ISBN 9781469630625
Содержание:
Introduction: How Did We Reach This Point? -- Why Regulate Medicines? -- Trials and Tribulations -- Dreams of Greatness: The Birth of the Pharmaceutical Industry -- Triumph and Tragedy -- Ivory Tower of Power -- The DNA of Biotechnology -- Blockbusters and Bombs: Pressures on the Pharmaceutical Industry -- Sea Monsters, Immunauts, and Death Panels -- Drama on the I-270 Tech Corridor -- Autophagy -- Three Views of a Train Wreck -- Bridging the Valley.
~РУБ DDC 615.1/9
Рубрики: Drug development.
Drugs--Research--Economic aspects.
Pharmaceutical industry.
Drugs--Design.
Drug Design
Drug Industry
Médicaments--Développement.
Médicaments--Recherche--Aspect économique.
Industrie pharmaceutique.
Médicaments--Conception.
MEDICAL--Pharmacology.
BUSINESS & ECONOMICS--Development--Business Development.
Drug development.
Drugs--Research--Economic aspects.
Pharmaceutical industry.
Аннотация: The introduction of new medicines has dramatically improved the quantity and quality of individual and public health while contributing trillions of dollars to the global economy. In spite of these past successes -- and indeed because of them -- our ability to deliver new medicines may be quickly coming to an end. Moving from the beginning of the twentieth century to the present, A Prescription for Change reveals how changing business strategies combined with scientific hubris have altered the way new medicines are discovered, with dire implications for both health and the economy. To explain how we have arrived at this pivotal moment, Michael Kinch recounts the history of pharmaceutical and biotechnological advances in the twentieth century. Kinch relates stories of the individuals and organizations that built the modern infrastructure that supports the development of innovative new medicines. He shows that an accelerating cycle of acquisition and downsizing is cannibalizing that infrastructure Kinch demonstrates the dismantling of the pharmaceutical and biotechnological research and development enterprises could also provide opportunities to innovate new models that sustain and expand the introduction of newer and better breakthrough medicines in the years to come. - Publisher.
K 46
Kinch, Michael, (1966-).
A prescription for change : : the looming crisis in drug development / / Michael S. Kinch. - Chapel Hill : : The University of North Carolina Press,, 2016. - 1 online resource (xi, 339 pages). - (The Luther H. Hodges Jr. and Luther H. Hodges Sr. series on business, entrepreneurship, and public policy). - Includes bibliographical references and index. - URL: https://library.dvfu.ru/lib/document/SK_ELIB/528D36D6-0AF5-481D-8D93-B30C48AA36D7. - ISBN 1469630648 (electronic bk.). - ISBN 9781469630649 (electronic bk.)
Print version record.
Параллельные издания: Print version: : Kinch, Michael S. Prescription for change. - Chapel Hill : University of North Carolina Press, [2016]. - ISBN 9781469630625
Содержание:
Introduction: How Did We Reach This Point? -- Why Regulate Medicines? -- Trials and Tribulations -- Dreams of Greatness: The Birth of the Pharmaceutical Industry -- Triumph and Tragedy -- Ivory Tower of Power -- The DNA of Biotechnology -- Blockbusters and Bombs: Pressures on the Pharmaceutical Industry -- Sea Monsters, Immunauts, and Death Panels -- Drama on the I-270 Tech Corridor -- Autophagy -- Three Views of a Train Wreck -- Bridging the Valley.
Рубрики: Drug development.
Drugs--Research--Economic aspects.
Pharmaceutical industry.
Drugs--Design.
Drug Design
Drug Industry
Médicaments--Développement.
Médicaments--Recherche--Aspect économique.
Industrie pharmaceutique.
Médicaments--Conception.
MEDICAL--Pharmacology.
BUSINESS & ECONOMICS--Development--Business Development.
Drug development.
Drugs--Research--Economic aspects.
Pharmaceutical industry.
Аннотация: The introduction of new medicines has dramatically improved the quantity and quality of individual and public health while contributing trillions of dollars to the global economy. In spite of these past successes -- and indeed because of them -- our ability to deliver new medicines may be quickly coming to an end. Moving from the beginning of the twentieth century to the present, A Prescription for Change reveals how changing business strategies combined with scientific hubris have altered the way new medicines are discovered, with dire implications for both health and the economy. To explain how we have arrived at this pivotal moment, Michael Kinch recounts the history of pharmaceutical and biotechnological advances in the twentieth century. Kinch relates stories of the individuals and organizations that built the modern infrastructure that supports the development of innovative new medicines. He shows that an accelerating cycle of acquisition and downsizing is cannibalizing that infrastructure Kinch demonstrates the dismantling of the pharmaceutical and biotechnological research and development enterprises could also provide opportunities to innovate new models that sustain and expand the introduction of newer and better breakthrough medicines in the years to come. - Publisher.
2.
Подробнее
M 61
Methods and algorithms for molecular docking-based drug design and discovery / / Siavoush Dastmalchi, Maryam Hamzeh-Mivehroud, and Babak Sokouti, editors. - 4018/978-1-5225-0115-2. - Hershey, Pennsylvania (701 E. Chocolate Avenue, Hershey, PA 17033, USA) : : IGI Global,, [2016]. - 1 online resource (PDFs (456 pages)) : : il ( час. мин.), 4018/978-1-5225-0115-2. - (Advances in medical technologies and clinical practice (AMTCP) book series). - Includes bibliographical references and index. - URL: https://library.dvfu.ru/lib/document/SK_ELIB/37923694-5316-4846-8EFE-47D024EA5D2B. - ISBN 9781522501169 (electronic bk.). - ISBN 1522501169 (electronic bk.)
Title screen (IGI Global, viewed 05/05/2016).
Параллельные издания: Print version: :
Содержание:
Molecular docking at a glance / Maryam Hamzeh-Mivehroud, Babak Sokouti, Siavoush Dastmalchi -- Methods for docking and drug designing / Ahmad Abu Turab Naqvi, Md. Imtaiyaz Hassan -- Scoring functions in docking experiments / Pravin Ambure, Kunal Roy -- The comparison of docking search algorithms and scoring functions: an overview and case studies / Marjana Novic [and 4 others] -- Protein ligand interaction fingerprints / Ali HajiEbrahimi [and 3 others] -- Different types of molecular docking based on variations of interacting molecules: variations of molecular docking / Amit Das, Simanti Bhattacharya -- Protein-protein docking: are we there yet? / Horia Jalily Hasani, Khaled H. Barakat -- Protein-ligand docking methodologies and its application in drug discovery / Sanchaita Rajkhowa, Ramesh C. Deka -- Scoring functions of protein-ligand interactions / Zhiqiang Yan, Jin Wang -- Molecular docking technique to understand enzyme-ligand interactions / Kailas Dashrath Sonawane, Maruti Jayram Dhanavade -- Recent advancements in docking methodologies / Vijay Kumar Srivastav, Vineet Singh, Meena Tiwari -- Docking methodologies and recent advances / Ashwani Kumar, Ruchika Goyal, Sandeep Jain -- Current trends in docking methodologies / Shubhandra Tripathi [and 3 others] -- Protein structure prediction using homology modeling: methods and tools / Akanksha Gupta, Pallavi Mohanty, Sonika Bhatnagar -- Online molecular docking resources / Adriana Isvoran.
~РУБ DDC 615.1/9
Рубрики: Pharmaceutical technology.
Drugs--Design--Computer simulation.
Algorithms.
Drugs--Design.
Drug Design
Molecular Docking Simulation
Algorithms
Technology, Pharmaceutical
Techniques pharmaceutiques.
Médicaments--Conception--Simulation par ordinateur.
Algorithmes.
Médicaments--Conception.
algorithms.
MEDICAL--Pharmacology.
Algorithms.
Drugs--Design--Computer simulation.
Pharmaceutical technology.
Кл.слова (ненормированные):
Docking methodologies -- Docking search algorithms -- Enzyme-ligand interactions -- Online docking resources -- Protein structure prediction -- Protein-ligand interactions -- Protein-protein docking
Аннотация: "This book investigates the evolution of pharmaceutical design and computational approaches in the field of molecular docking, highlighting theoretical backgrounds and emergent research in the area of computer-assisted drug design"--Provided by publisher.
Доп.точки доступа:
Dastmalchi, Siavoush, (1966-) \editor.\
Hamzeh-Mivehroud, Maryam, (1981-) \editor.\
Sokouti, Babak, (1978-) \editor.\
IGI Global,
M 61
Methods and algorithms for molecular docking-based drug design and discovery / / Siavoush Dastmalchi, Maryam Hamzeh-Mivehroud, and Babak Sokouti, editors. - 4018/978-1-5225-0115-2. - Hershey, Pennsylvania (701 E. Chocolate Avenue, Hershey, PA 17033, USA) : : IGI Global,, [2016]. - 1 online resource (PDFs (456 pages)) : : il ( час. мин.), 4018/978-1-5225-0115-2. - (Advances in medical technologies and clinical practice (AMTCP) book series). - Includes bibliographical references and index. - URL: https://library.dvfu.ru/lib/document/SK_ELIB/37923694-5316-4846-8EFE-47D024EA5D2B. - ISBN 9781522501169 (electronic bk.). - ISBN 1522501169 (electronic bk.)
Title screen (IGI Global, viewed 05/05/2016).
Параллельные издания: Print version: :
Содержание:
Molecular docking at a glance / Maryam Hamzeh-Mivehroud, Babak Sokouti, Siavoush Dastmalchi -- Methods for docking and drug designing / Ahmad Abu Turab Naqvi, Md. Imtaiyaz Hassan -- Scoring functions in docking experiments / Pravin Ambure, Kunal Roy -- The comparison of docking search algorithms and scoring functions: an overview and case studies / Marjana Novic [and 4 others] -- Protein ligand interaction fingerprints / Ali HajiEbrahimi [and 3 others] -- Different types of molecular docking based on variations of interacting molecules: variations of molecular docking / Amit Das, Simanti Bhattacharya -- Protein-protein docking: are we there yet? / Horia Jalily Hasani, Khaled H. Barakat -- Protein-ligand docking methodologies and its application in drug discovery / Sanchaita Rajkhowa, Ramesh C. Deka -- Scoring functions of protein-ligand interactions / Zhiqiang Yan, Jin Wang -- Molecular docking technique to understand enzyme-ligand interactions / Kailas Dashrath Sonawane, Maruti Jayram Dhanavade -- Recent advancements in docking methodologies / Vijay Kumar Srivastav, Vineet Singh, Meena Tiwari -- Docking methodologies and recent advances / Ashwani Kumar, Ruchika Goyal, Sandeep Jain -- Current trends in docking methodologies / Shubhandra Tripathi [and 3 others] -- Protein structure prediction using homology modeling: methods and tools / Akanksha Gupta, Pallavi Mohanty, Sonika Bhatnagar -- Online molecular docking resources / Adriana Isvoran.
Рубрики: Pharmaceutical technology.
Drugs--Design--Computer simulation.
Algorithms.
Drugs--Design.
Drug Design
Molecular Docking Simulation
Algorithms
Technology, Pharmaceutical
Techniques pharmaceutiques.
Médicaments--Conception--Simulation par ordinateur.
Algorithmes.
Médicaments--Conception.
algorithms.
MEDICAL--Pharmacology.
Algorithms.
Drugs--Design--Computer simulation.
Pharmaceutical technology.
Кл.слова (ненормированные):
Docking methodologies -- Docking search algorithms -- Enzyme-ligand interactions -- Online docking resources -- Protein structure prediction -- Protein-ligand interactions -- Protein-protein docking
Аннотация: "This book investigates the evolution of pharmaceutical design and computational approaches in the field of molecular docking, highlighting theoretical backgrounds and emergent research in the area of computer-assisted drug design"--Provided by publisher.
Доп.точки доступа:
Dastmalchi, Siavoush, (1966-) \editor.\
Hamzeh-Mivehroud, Maryam, (1981-) \editor.\
Sokouti, Babak, (1978-) \editor.\
IGI Global,
3.
Подробнее
A 67
Applied case studies and solutions in molecular docking-based drug design / / Siavoush Dastmalchi, Tabriz University of Medical Sciences, Iran, Maryam Hamzeh-Mivehroud, Tabriz University of Medical Sciences, Iran, and Babak Sokouti, Tabriz University of Medical Sciences, Iran, editors. - Hersey, PA : : Medical Information Science Reference, an imprint of IGI Global,, [2016]. - 1 online resource (xvii, 367 pages) : : il. - Includes bibliographical references and index. - URL: https://library.dvfu.ru/lib/document/SK_ELIB/97534DD4-1261-4900-ABF7-6C11F8C95E91. - ISBN 9781522503637 (electronic bk.). - ISBN 1522503633 (electronic bk.)
Содержание:
Role of molecular docking in computer-aided drug design and development / Rahul Agarwal, Ashutosh Singh, Subhabrata Sen -- Application of docking methodologies in QSAR-based studies / Omar Deeb [and 3 others] -- Molecular docking challenges and limitations / Jahan B. Ghasemi, Azizeh Abdolmaleki, Fereshteh Shiri -- Application of molecular docking in studies on the binding mechanism of three enzymes with natural products / Hua-jin Zeng, Ran Yang, Ling-bo Qu -- Molecular docking of biologically active substances to double helical nucleic acids: problems and solutions / Kateryna V. Miroshnychenko, Anna V. Shestopalova -- Molecular-docking-based drug design and discovery: rational drug design for the subtype selective GPCR ligands / Soo-Kyung Kim, William A. Goddard III -- Molecular modelling, dynamics, and docking of membrane proteins: still a challenge / Nanda Kumar Yellapu -- In silico perspective into interactions and mutations in human TLR4 and Ebola glycoprotein / Sujay Ray, Arundhati Banerjee -- Molecular-docking-based anti-allergic drug design / Anamika Basu, Piyali Basak, Anasua Sarkar -- Protein-protein interactions (PPIs) as an alternative to targeting the ATP binding site of kinase: in silico approach to Identify PPI Inhibitors / Sailu Sarvagalla, Mohane Selvaraj Coumar -- Applications of molecular docking: its impact and importance outside the purview of drug discovery / Josephine Anthony [and 4 others].
~РУБ DDC 615.1/9
Рубрики: Pharmaceutical technology.
Drugs--Design--Computer simulation.
Drugs--Design.
Drug Design
Molecular Docking Simulation
Technology, Pharmaceutical
Techniques pharmaceutiques.
Médicaments--Conception--Simulation par ordinateur.
Médicaments--Conception.
MEDICAL / Pharmacology
Drugs--Design--Computer simulation.
Pharmaceutical technology.
Аннотация: "This book is a pivotal reference source for the latest scholarly research on the progress of pharmaceutical design and computational approaches in the field of molecular docking, highlighting innovative research perspectives and real-world applications"--
Доп.точки доступа:
Dastmalchi, Siavoush.
Hamzeh-Mivehroud, Maryam.
Sokouti, Babak.
A 67
Applied case studies and solutions in molecular docking-based drug design / / Siavoush Dastmalchi, Tabriz University of Medical Sciences, Iran, Maryam Hamzeh-Mivehroud, Tabriz University of Medical Sciences, Iran, and Babak Sokouti, Tabriz University of Medical Sciences, Iran, editors. - Hersey, PA : : Medical Information Science Reference, an imprint of IGI Global,, [2016]. - 1 online resource (xvii, 367 pages) : : il. - Includes bibliographical references and index. - URL: https://library.dvfu.ru/lib/document/SK_ELIB/97534DD4-1261-4900-ABF7-6C11F8C95E91. - ISBN 9781522503637 (electronic bk.). - ISBN 1522503633 (electronic bk.)
Содержание:
Role of molecular docking in computer-aided drug design and development / Rahul Agarwal, Ashutosh Singh, Subhabrata Sen -- Application of docking methodologies in QSAR-based studies / Omar Deeb [and 3 others] -- Molecular docking challenges and limitations / Jahan B. Ghasemi, Azizeh Abdolmaleki, Fereshteh Shiri -- Application of molecular docking in studies on the binding mechanism of three enzymes with natural products / Hua-jin Zeng, Ran Yang, Ling-bo Qu -- Molecular docking of biologically active substances to double helical nucleic acids: problems and solutions / Kateryna V. Miroshnychenko, Anna V. Shestopalova -- Molecular-docking-based drug design and discovery: rational drug design for the subtype selective GPCR ligands / Soo-Kyung Kim, William A. Goddard III -- Molecular modelling, dynamics, and docking of membrane proteins: still a challenge / Nanda Kumar Yellapu -- In silico perspective into interactions and mutations in human TLR4 and Ebola glycoprotein / Sujay Ray, Arundhati Banerjee -- Molecular-docking-based anti-allergic drug design / Anamika Basu, Piyali Basak, Anasua Sarkar -- Protein-protein interactions (PPIs) as an alternative to targeting the ATP binding site of kinase: in silico approach to Identify PPI Inhibitors / Sailu Sarvagalla, Mohane Selvaraj Coumar -- Applications of molecular docking: its impact and importance outside the purview of drug discovery / Josephine Anthony [and 4 others].
Рубрики: Pharmaceutical technology.
Drugs--Design--Computer simulation.
Drugs--Design.
Drug Design
Molecular Docking Simulation
Technology, Pharmaceutical
Techniques pharmaceutiques.
Médicaments--Conception--Simulation par ordinateur.
Médicaments--Conception.
MEDICAL / Pharmacology
Drugs--Design--Computer simulation.
Pharmaceutical technology.
Аннотация: "This book is a pivotal reference source for the latest scholarly research on the progress of pharmaceutical design and computational approaches in the field of molecular docking, highlighting innovative research perspectives and real-world applications"--
Доп.точки доступа:
Dastmalchi, Siavoush.
Hamzeh-Mivehroud, Maryam.
Sokouti, Babak.
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